Restricting 2 Amino Acids eliminated Cancer in Clinical Trial!
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AI Summary of "Restricting 2 Amino Acids eliminated Cancer in Clinical Trial!"
Get instant insights and key takeaways from this YouTube video by Physionic.
Dietary Restriction and Cancer Treatment
📌 A clinical trial showed that restricting the amino acids serine and glycine led to tumors shrinking or evaporating in human cancer patients, sometimes within 9 weeks.
🔬 The mechanism relies on the immune system, specifically CD8 positive cytotoxic T-cells, which attack cancer cells after the amino acid restriction forces cancer cells to become vulnerable.
🧪 This restriction is intended to be paired with immunotherapy that targets the specific immune evasion technique cancer cells use to survive the deprivation.
📊 In the trial, which included colorectal, esophageal, gastric, and liver cancers, most patients experienced tumor reduction, although some saw progression.
Clinical Trial Specifics and Context
🥩 Participants followed a diet devoid of serine and glycine for 9-week cycles, while maintaining adequate nutrition (around 3,000 kCal/day and 150 g of protein for a 100 kg person).
⚠️ The study was a Phase One clinical trial and lacked a control group, meaning it's unclear if the progression seen in some patients would have been worse without the treatment.
⚠️ The effectiveness varied, possibly due to the type of cancer or the duration of exposure (longer adherence often correlating with better outcomes).
Amino Acid Nuances and Applicability
🚫 Glycine and serine are not essential amino acids, making complete dietary elimination difficult as many foods contain them; this protocol required specialized nutrition.
❗ For healthy individuals (not diagnosed with cancer), there is no evidence suggesting they should limit glycine consumption, and some research even suggests glycine supplementation may help fight cancer in certain contexts.
🔄 Cancer response is highly nuanced; while restriction helped many, the role of glycine specifically varies, with it being potentially effective against some cancers but detrimental to others.
Key Points & Insights
➡️ Serine and glycine restriction utilizes the body’s own cytotoxic T-cells to target and destroy cancer cells when combined with specific immunotherapy.
➡️ The protocol showed slowing or reversing of cancer in the majority of early human study participants when paired with targeted immunotherapy.
➡️ Implementing this dietary change outside of a clinical trial setting is challenging due to the necessity of specialized, highly restricted diets to effectively remove these amino acids.
➡️ Healthy individuals should not restrict glycine or serine intake based on this research, as its application is highly specific to cancer treatment protocols.
📸 Video summarized with SummaryTube.com on Dec 22, 2025, 13:55 UTC
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📜Transcript
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Vitamin C on Cancer - an Untold Story: https://youtu.be/e6jjRy7fj5E?si=PO8sHlRENl6wjEAl
0:00 - Remarkable Images of Tumor Disappearance
0:25 - The Amino Acids
0:55 - Different Cancers - Not just Colorectal
1:07 - The Protocol Effectiveness
2:10 - Cancer Evasion - A Double Dose Needed
2:45 - The Protocol
3:30 - Not 100% Effective - Why Not?
6:21 - Keep in Mind...
7:39 - Should Glycine Supplementation be Stopped?
8:43 - Main Points
Reference
[Study 561] Tong H, Jiang Z, Song L, et al. Dual impacts of serine/glycine-free diet in enhancing antitumor immunity and promoting evasion via PD-L1 lactylation. Cell Metab. 2024;36(12):2493-2510. doi:10.1016/j.cmet.2024.10.019
Funding / Conflicts: Public: This study was supported by the Science and Technology Program of Sichuan Province (2022NSFSC0774); this study was supported by the National Natural Science Foundation of China (82273030 and 82472869); no public-sector conflicts of interest were declared; Non-Profit: This study was supported by the 2021 Xinrui Tumor Supportive Treatment Research Public Welfare Project (311221042); no non-profit conflicts of interest were declared; Industry: Junshi Biosciences provided PD-1 inhibitors; Shanghai Sinotech Genomics Co., Ltd. provided single-cell sequencing services and Shanghai Personal Biotechnology Co., Ltd. provided PD-L1 lactylation-related and metabolomics/TCR sequencing services; Recovery Plus Clinic Co. funded targeted amino acid metabolism testing and some other sequencing services for the project; conflicts of interest: C.H. and Z. Lei are shareholders and board members of Recovery Plus Clinic Co., and Z. Long and J.Y. are also members of this company (the authors note potential bias and state independent/unaffiliated researchers were included to mitigate this).
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#cancertherapy #cancertreatment #cancerprevention
Full video URL: youtube.com/watch?v=c74fifu54Sg
Duration: 9:26
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AI Summary of "Restricting 2 Amino Acids eliminated Cancer in Clinical Trial!"
Get instant insights and key takeaways from this YouTube video by Physionic.
Dietary Restriction and Cancer Treatment
📌 A clinical trial showed that restricting the amino acids serine and glycine led to tumors shrinking or evaporating in human cancer patients, sometimes within 9 weeks.
🔬 The mechanism relies on the immune system, specifically CD8 positive cytotoxic T-cells, which attack cancer cells after the amino acid restriction forces cancer cells to become vulnerable.
🧪 This restriction is intended to be paired with immunotherapy that targets the specific immune evasion technique cancer cells use to survive the deprivation.
📊 In the trial, which included colorectal, esophageal, gastric, and liver cancers, most patients experienced tumor reduction, although some saw progression.
Clinical Trial Specifics and Context
🥩 Participants followed a diet devoid of serine and glycine for 9-week cycles, while maintaining adequate nutrition (around 3,000 kCal/day and 150 g of protein for a 100 kg person).
⚠️ The study was a Phase One clinical trial and lacked a control group, meaning it's unclear if the progression seen in some patients would have been worse without the treatment.
⚠️ The effectiveness varied, possibly due to the type of cancer or the duration of exposure (longer adherence often correlating with better outcomes).
Amino Acid Nuances and Applicability
🚫 Glycine and serine are not essential amino acids, making complete dietary elimination difficult as many foods contain them; this protocol required specialized nutrition.
❗ For healthy individuals (not diagnosed with cancer), there is no evidence suggesting they should limit glycine consumption, and some research even suggests glycine supplementation may help fight cancer in certain contexts.
🔄 Cancer response is highly nuanced; while restriction helped many, the role of glycine specifically varies, with it being potentially effective against some cancers but detrimental to others.
Key Points & Insights
➡️ Serine and glycine restriction utilizes the body’s own cytotoxic T-cells to target and destroy cancer cells when combined with specific immunotherapy.
➡️ The protocol showed slowing or reversing of cancer in the majority of early human study participants when paired with targeted immunotherapy.
➡️ Implementing this dietary change outside of a clinical trial setting is challenging due to the necessity of specialized, highly restricted diets to effectively remove these amino acids.
➡️ Healthy individuals should not restrict glycine or serine intake based on this research, as its application is highly specific to cancer treatment protocols.
📸 Video summarized with SummaryTube.com on Dec 22, 2025, 13:55 UTC
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As an Amazon Associate, we earn from qualifying purchases
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