25 Year Study: The Dairy Fat Finding That’s Uncomfortable for Both Sides
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AI Summary of "25 Year Study: The Dairy Fat Finding That’s Uncomfortable for Both Sides"
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High-Fat Cheese and Dementia Risk
📌 A large study involving around 27,000 people over 25 years indicated that the highest consumption of high-fat cheese (defined as fat, e.g., Brie, Gouda, Cheddar) was linked to a reduced risk of dementia.
🔬 This reduced risk persisted even after researchers performed adjustments and sensitivity analyses, like lag analysis, to control for confounding factors.
📉 A major limitation is diet drift, as restricting the analysis to those who did not significantly change their diet resulted in the relationship vanishing, though this also involved losing of participants.
Critique and Corroborating Evidence
🧐 One primary critique was reverse causation (people with poor health switching to low-fat dairy), but sensitivity analyses suggested the protective relationship remained.
🇯🇵 A study in Japanese adults showed that cheese consumers had lower rates of dementia compared to non-consumers, although this finding was from a shorter study duration and showed a relatively small difference.
inconclusive results were found in a smaller intervention study where non-fermented cheese (mozzarella/cream cheese) provided a very slight improvement in cognitive function, while fermented cheese (Camembert) showed no benefit.
Heavy Cream and Mechanisms
🥛 The analysis of heavy cream consumption also suggested a healthful relationship, showing a reduced risk of dementia, which remained true after sensitivity analyses.
🧪 The exact mechanisms are unknown, but one RCT showed an increase in the brain-boosting molecule BDNF (Brain-Derived Neurotrophic Factor) when consuming fermented cheese, though this cheese did not show cognitive benefits.
💡 Potential beneficial components in high-fat cheeses include specific types of saturated fats and nutrients like Vitamin K2, which supports neuron structure (myelin) and survival.
Key Points & Insights
➡️ For cheese lovers, the current data suggests high-fat cheeses may offer a mild protective benefit against dementia, making current consumption habits potentially beneficial for brain health.
➡️ While there is supporting evidence, the results concerning heavy cream are considered shakier due to fewer corroborating studies, requiring more data before making strong recommendations.
➡️ Overall, the evidence suggests cheese is at least not harmful to brain function, and for those who enjoy it, it may be providing some mild protection against dementia as a class of disorders.
📸 Video summarized with SummaryTube.com on Jan 15, 2026, 15:01 UTC
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📜Transcript
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Created with Biorender
Fat with Dementia Protection: https://youtu.be/7UsRrTwXe3Y?si=G6cMingMETzLs3ar
0:00 - Introduction
0:48 - High Fat Cheese: Not so Bad after All
2:02 - Addressing Critiques
5:00 - Let’s not Pretend…
9:26 - Caution and Care
10:41 - Mysteries of Cheese
12:18 - Heavy Cream, please…
References
[Study 579] Du Y, Borné Y, Samuelsson J, Glans I, Hu X, Nägga K, et al. High- and low-fat dairy consumption and long-term risk of dementia: evidence from a 25-year prospective cohort study. Neurology. 2026;106(2):e214343. doi:10.1212/WNL.0000000000214343.
Funding/Conflicts: Public: The study was funded by public/government sources including the Swedish Research Council (2020-01412; plus individual support to S. Palmqvist, 2018-02052; and O. Hansson, 2022-00775), the European Research Council (ADG-101096455), the US National Institute on Aging (R01AG083740), and Swedish federal/regional public support (ALF agreement 2022-Projekt0080; Regionalt Forskningsstöd 2022-1259); no additional public-sector conflicts are disclosed beyond the author disclosures listed below. Non-Profit: Non-profit/foundation funding included the Heart and Lung Foundation, Crafoord Foundation, Magnus Bergvall Foundation, Albert Påhlsson Foundation, Swedish Brain Foundation, Swedish Alzheimer Foundation, Alzheimer’s Association, GHR Foundation, Knut and Alice Wallenberg Foundation, Parkinson foundation of Sweden, Cure Alzheimer’s fund, Rönström Family Foundation, and Konung Gustaf V:s och Drottning Victorias Frimurarestiftelse (plus related institutional foundation support noted in the paper); no non-profit-specific conflicts are disclosed beyond the author disclosures listed below. Industry: S. Palmqvist reports institutional research support from Avid and Ki Elements (through ADDF) and consultancy/speaker fees from Bioartic, Biogen, Eisai, Eli Lilly, Novo Nordisk, and Roche; O. Hansson is an employee of Lund University and Eli Lilly; all other authors report no disclosures relevant to the manuscript.
[Study 580] Jeong S, Suzuki T, Inoue Y, et al. Cheese consumption and incidence of dementia in community-dwelling older Japanese adults: the JAGES 2019–2022 cohort study. Nutrients. 2025;17(21):3363. doi:10.3390/nu17213363.
[Study 581] Dobreva I, Marston L, Mukadam N. Which components of the Mediterranean diet are associated with dementia? A UK Biobank cohort study. GeroScience. 2022;44:2541-2554. doi:10.1007/s11357-022-00615-2.
[Study 582] Ylilauri MPT, Hantunen S, Lönnroos E, Salonen JT, Tuomainen T-P, Virtanen JK. Associations of dairy, meat, and fish intakes with risk of incident dementia and with cognitive performance: the Kuopio Ischaemic Heart Disease Risk Factor Study (KIHD). Eur J Nutr. 2022;61:2531-2542. doi:10.1007/s00394-022-02834-x.
[Study 583] Suzuki T, Kojima N, Osuka Y, Tokui Y, Takasugi S, Kawashima A, et al. The effects of mold-fermented cheese on brain-derived neurotrophic factor in community-dwelling older Japanese women with mild cognitive impairment: a randomized, controlled, crossover trial. J Am Med Dir Assoc. 2019;20(12):1505-1511.e2. doi:10.1016/j.jamda.2019.06.023.
********CRITIQUES, RULES, AND NOTES********
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Full video URL: youtube.com/watch?v=DvPstF4evqo
Duration: 13:41
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AI Summary of "25 Year Study: The Dairy Fat Finding That’s Uncomfortable for Both Sides"
Get instant insights and key takeaways from this YouTube video by Physionic.
High-Fat Cheese and Dementia Risk
📌 A large study involving around 27,000 people over 25 years indicated that the highest consumption of high-fat cheese (defined as fat, e.g., Brie, Gouda, Cheddar) was linked to a reduced risk of dementia.
🔬 This reduced risk persisted even after researchers performed adjustments and sensitivity analyses, like lag analysis, to control for confounding factors.
📉 A major limitation is diet drift, as restricting the analysis to those who did not significantly change their diet resulted in the relationship vanishing, though this also involved losing of participants.
Critique and Corroborating Evidence
🧐 One primary critique was reverse causation (people with poor health switching to low-fat dairy), but sensitivity analyses suggested the protective relationship remained.
🇯🇵 A study in Japanese adults showed that cheese consumers had lower rates of dementia compared to non-consumers, although this finding was from a shorter study duration and showed a relatively small difference.
inconclusive results were found in a smaller intervention study where non-fermented cheese (mozzarella/cream cheese) provided a very slight improvement in cognitive function, while fermented cheese (Camembert) showed no benefit.
Heavy Cream and Mechanisms
🥛 The analysis of heavy cream consumption also suggested a healthful relationship, showing a reduced risk of dementia, which remained true after sensitivity analyses.
🧪 The exact mechanisms are unknown, but one RCT showed an increase in the brain-boosting molecule BDNF (Brain-Derived Neurotrophic Factor) when consuming fermented cheese, though this cheese did not show cognitive benefits.
💡 Potential beneficial components in high-fat cheeses include specific types of saturated fats and nutrients like Vitamin K2, which supports neuron structure (myelin) and survival.
Key Points & Insights
➡️ For cheese lovers, the current data suggests high-fat cheeses may offer a mild protective benefit against dementia, making current consumption habits potentially beneficial for brain health.
➡️ While there is supporting evidence, the results concerning heavy cream are considered shakier due to fewer corroborating studies, requiring more data before making strong recommendations.
➡️ Overall, the evidence suggests cheese is at least not harmful to brain function, and for those who enjoy it, it may be providing some mild protection against dementia as a class of disorders.
📸 Video summarized with SummaryTube.com on Jan 15, 2026, 15:01 UTC
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As an Amazon Associate, we earn from qualifying purchases
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