Are Urolithin A Longevity Supplements worth your Money?
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AI Summary of "Are Urolithin A Longevity Supplements worth your Money?"
Get instant insights and key takeaways from this YouTube video by Physionic.
Urolithin Supplementation: Immune Effects
📌 A new randomized control trial focused on the effect of urolithin on age-related immune decline over one month in people in their 50s.
🔬 Urolithin consumption led to a statistically significant rise in specialized immune cells, specifically CD8 T cells, which are crucial for fighting pathogens and cancer.
🦠 Supplementation also resulted in an elevation of cancer-killing cells, such as Natural Killer (NK) cells.
Cellular Mechanism and Anti-inflammation
🧬 Urolithin consumption increases PGC-1 alpha, a master protein that signals for mitochondrial biogenesis (growth) within immune cells, suggesting improved metabolic flexibility.
🔥 The study also indicated an anti-inflammatory effect from urolithin supplementation, countering age-related pro-inflammation.
Critique of Urolithin Efficacy
📉 The positive effects demonstrated in studies are often not functional endpoints (e.g., feeling less pain) but mechanistic, often showing only small, single-digit percentage improvements compared to placebo.
🔬 A major concern is that most studies showing benefits are funded by, or involve researchers employed by, a urolithin supplement company.
⏱️ Current research utilizes short study durations (one month), meaning long-term cumulative effects remain unknown.
Key Points & Insights
➡️ While urolithin shows positive effects on immune profile, anti-inflammation, and mitochondrial signaling, the magnitude of benefit is often very small.
➡️ If an individual chooses to use urolithin, the effective dose utilized across the studies is 1,000 milligrams (mg) per day.
➡️ The overall recommendation is cautious skepticism, suggesting the benefits might not be worth the cost for most people unless targeted benefits are proven in longer studies.
📸 Video summarized with SummaryTube.com on Dec 06, 2025, 14:01 UTC
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0:00 - Introduction
0:48 - The Benefits of Urolithin A
4:40 - I discourage you..
8:15 - Context Matters
9:19 - Main Points / Key Takeaways
Other Urolithin A Analysis: https://youtu.be/cJdAlp2new4?si=J08IL1mSoPbhLst1
Reference
[Study 549] Denk D, Singh A, Kasler HG, et al. Effect of the mitophagy inducer urolithin A on age-related immune decline: a randomized, placebo-controlled trial. Nat Aging. 2025;5(11):2309-2322. doi:10.1038/s43587-025-00996-x
Funding/Conflicts: Public: this trial received public and institutional support for D. Denk and F.R.G. from the Deutsche Forschungsgemeinschaft (DFG; DE 4233/1-1, SFB1292, SFB1479, GRK2336), the German Federal Ministry of Education and Research (BMBF; 01KD2206Q/SATURN3), the European Research Council (Advanced Grant PLASTICAN-101021078), institutional funds from the Georg-Speyer-Haus, the LOEWE Center Frankfurt Cancer Institute funded by the Hessen State Ministry for Higher Education, Research and the Arts, and core funding of the Georg-Speyer-Haus jointly by the German Federal Ministry of Health and the Ministry of Higher Education, Research and the Arts of the State of Hessen, as well as support from the Clinical Trial Center Network of the Universitäres Centrum für Tumorerkrankungen (UCT) Frankfurt; Non-Profit: D. Denk was supported by the Mildred-Scheel Nachwuchszentrum Frankfurt funded by the German Cancer Aid (Deutsche Krebshilfe); Industry: UA (Mitopure) and study funds were provided by Amazentis SA, which co-designed this investigator-initiated trial but had no role in data collection, analysis, decision to publish or manuscript preparation, and several authors report industry-related competing interests, including employment of A.S., D. D’Amico and J.F. by Amazentis SA, C.R. serving as president and delegate of the board of Amazentis SA, consulting fees to F.R.G. from Amazentis, travel compensation to D. Denk from Amazentis and AbbVie, and restrictions on commercial use of SCENITH owing to a pending patent application (PCT/EP2020/WO2020212362A1 to R.J.A.), while the remaining authors declare no competing interests related to this study.
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Disclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.
#urolithina #timeline
Full video URL: youtube.com/watch?v=tyvIdb6xrnw
Duration: 20:09
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AI Summary of "Are Urolithin A Longevity Supplements worth your Money?"
Get instant insights and key takeaways from this YouTube video by Physionic.
Urolithin Supplementation: Immune Effects
📌 A new randomized control trial focused on the effect of urolithin on age-related immune decline over one month in people in their 50s.
🔬 Urolithin consumption led to a statistically significant rise in specialized immune cells, specifically CD8 T cells, which are crucial for fighting pathogens and cancer.
🦠 Supplementation also resulted in an elevation of cancer-killing cells, such as Natural Killer (NK) cells.
Cellular Mechanism and Anti-inflammation
🧬 Urolithin consumption increases PGC-1 alpha, a master protein that signals for mitochondrial biogenesis (growth) within immune cells, suggesting improved metabolic flexibility.
🔥 The study also indicated an anti-inflammatory effect from urolithin supplementation, countering age-related pro-inflammation.
Critique of Urolithin Efficacy
📉 The positive effects demonstrated in studies are often not functional endpoints (e.g., feeling less pain) but mechanistic, often showing only small, single-digit percentage improvements compared to placebo.
🔬 A major concern is that most studies showing benefits are funded by, or involve researchers employed by, a urolithin supplement company.
⏱️ Current research utilizes short study durations (one month), meaning long-term cumulative effects remain unknown.
Key Points & Insights
➡️ While urolithin shows positive effects on immune profile, anti-inflammation, and mitochondrial signaling, the magnitude of benefit is often very small.
➡️ If an individual chooses to use urolithin, the effective dose utilized across the studies is 1,000 milligrams (mg) per day.
➡️ The overall recommendation is cautious skepticism, suggesting the benefits might not be worth the cost for most people unless targeted benefits are proven in longer studies.
📸 Video summarized with SummaryTube.com on Dec 06, 2025, 14:01 UTC
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As an Amazon Associate, we earn from qualifying purchases
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